It is our pleasure to invite you to the LS2 Annual Meeting 2022 on the topic “Life Sciences in the 2020s: quantitation, integration and prediction", held on February 17 and 18, 2022, together with the Young Scientists' Satellite on February 16, 2022 in Zurich, at campus Irchel of the University of Zurich. The LS2 Annual Meeting brings together scientists from all nations and backgrounds to explore the large spectrum united under the umbrella of Life Sciences. The 2022 edition is being organized to be an on-site meeting with all safety measures in place. We know the situation may change from now to February 2022, therefore in case specific rules are needed, they will be announced in due course. The program will include 3 plenary lectures, a symposium organized by and for young scientists with short talks selected from abstracts, our already famous PIs of Tomorrow session, the lectures from 3 awards (Prix Schläfli, Lelio Orci Award and Friedrich Miescher Award), a special plenary short talk "Personalized Health" from the Forum of Genetic Research (SCNAT) and 11 scientific symposia organized by our sections and partners.